apalutamide will lessen the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with prescription drugs which are CYP3A4 substrates may lead to lessen exposure to those prescription drugs.fentanyl iontophoretic tra